Generic Name: amlodipine, hydrochlorothiazide, and valsartan (am LOE di peen, HYE droe klor oh THYE a zide, val SAR tan)
Brand Names: Exforge HCT
What is amlodipine, hydrochlorothiazide, and valsartan?
Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Valsartan is an angiotensin II receptor antagonists. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
The combination of amlodipine, hydrochlorothiazide, and valsartan is used to treat high blood pressure (hypertension).
This medication is usually given after other blood pressure medications have been tried without successful treatment of symptoms.
Amlodipine, hydrochlorothiazide, and valsartan may also be used for purposes not listed in this medication guide.
What is the most important information I should know about amlodipine, hydrochlorothiazide, and valsartan?
Your chest pain may become worse when you first start taking this medication or when your dose is increased. Call your doctor if your chest pain is severe or ongoing. You should not take this medication if you are allergic to amlodipine (Norvasc), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic and others), valsartan (Diovan), or sulfa drugs, or if you are unable to urinate.
Before taking amlodipine, hydrochlorothiazide, and valsartan, tell your doctor if you have kidney or liver disease, congestive heart failure, glaucoma, asthma or allergies, low or high blood levels of potassium, gout, lupus, diabetes, or a pencillin allergy.
Do not use this medication without telling your doctor if you are pregnant. Amlodipine, hydrochlorothiazide, and valsartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. Drinking alcohol can further lower your blood pressure and may increase certain side effects of amlodipine, hydrochlorothiazide, and valsartan. Do not use potassium supplements or salt substitutes while you are taking amlodipine, hydrochlorothiazide, and valsartan, unless your doctor has told you to.
What should I discuss with my healthcare provider before taking amlodipine, hydrochlorothiazide, and valsartan?
You should not take this medication if you are allergic to amlodipine (Norvasc), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic and others), valsartan (Diovan), or sulfa drugs, or if you are unable to urinate.
To make sure you can safely take amlodipine, hydrochlorothiazide, and valsartan, tell your doctor if you have any of these other conditions:
- kidney disease;
- liver disease;
congestive heart failure;
glaucoma;
asthma or allergies;
low or high levels of magnesium or potassium in your blood;
gout;
lupus;
diabetes; or
a penicillin allergy.
FDA pregnancy category D. Do not use this medication if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Amlodipine, hydrochlorothiazide, and valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking amlodipine, hydrochlorothiazide, and valsartan. Amlodipine, hydrochlorothiazide, and valsartan can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using amlodipine, hydrochlorothiazide, and valsartan.
How should I take amlodipine, hydrochlorothiazide, and valsartan?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
Take this medication with a full glass (8 ounces) of water. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your chest pain may become worse when you first start taking this medication or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
Your blood pressure will need to be checked often. Visit your doctor regularly.
It may take up to 2 weeks of using this medicine before your blood pressure improves. For best results, keep using the medication as directed.
Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
See also: Amlodipine, hydrochlorothiazide, and valsartan dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include fast or slow heartbeat, confusion, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; feeling light-headed, and fainting.
What should I avoid while taking amlodipine, hydrochlorothiazide, and valsartan?
Drinking alcohol can further lower your blood pressure and may increase certain side effects of amlodipine, hydrochlorothiazide, and valsartan. Do not use potassium supplements or salt substitutes while you are taking amlodipine, hydrochlorothiazide, and valsartan, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Amlodipine, hydrochlorothiazide, and valsartan side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
eye pain, vision problems;
feeling like you might pass out;
swelling, rapid weight gain;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
slow, fast, or pounding heartbeats;
urinating less than usual, or not at all;
easy bruising or bleeding, unusual weakness;
numbness, tingling, or burning pain;
jaundice (yellowing of the skin or eyes); or
dry mouth, increased thirst, drowsiness, restless feeling, confusion, increased urination, fast heart rate, fainting, or seizure (convulsions).
Less serious side effects may include:
dizziness;
headache, tired feeling;
nausea, upset stomach;
muscle spasms, back pain; or
stuffy nose, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Amlodipine, hydrochlorothiazide, and valsartan Dosing Information
Usual Adult Dose for Hypertension:
Initial dose: Individualize based on the effectiveness and tolerance of each individual component, orally once daily.
Maintenance dose: Individualize based on the effectiveness and tolerance of each individual component, orally once daily. The dosage may be increased after two weeks of therapy. The full blood pressure lowering effect was achieved two weeks after being on the maximal dose.
Maximum dose: Amlodipine/hydrochlorothiazide/valsartan 10/25/320 mg orally once daily
What other drugs will affect amlodipine, hydrochlorothiazide, and valsartan?
Tell your doctor about all other medications you use, especially:
any other blood pressure medications;
steroids (prednisone and others);
carbamazepine (Carbatrol, Equetro, Tegretol);
lithium (Eskalith, Lithobid);
cholestyramine (Prevalite, Questran) or colestipol (Colestid);
insulin or oral diabetes medication;
simvastatin (Zocor, Simcor, Vytorin);
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
any other diuretics (water pills);
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex);
a narcotic medication such as hydrocodone (Lortab, Vicodin), meperidine (Demerol), methadone (Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin), and others.
This list is not complete and other drugs may interact with amlodipine, hydrochlorothiazide, and valsartan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More amlodipine, hydrochlorothiazide, and valsartan resources
- Amlodipine, hydrochlorothiazide, and valsartan Dosage
- Amlodipine, hydrochlorothiazide, and valsartan Use in Pregnancy & Breastfeeding
- Amlodipine, hydrochlorothiazide, and valsartan Drug Interactions
- Amlodipine, hydrochlorothiazide, and valsartan Support Group
- 1 Review for Amlodipine, hydrochlorothiazide, and valsartan - Add your own review/rating
Compare amlodipine, hydrochlorothiazide, and valsartan with other medications
- High Blood Pressure
Where can I get more information?
- Your pharmacist can provide more information about amlodipine, hydrochlorothiazide, and valsartan.
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